https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular sorts with recombination perform.
[Laughs] ‘It was definitely a great threat! At time, I was well aware that it could go wrong Which I could develop into a lot less profitable, but I just dismissed that. Curiosity has often been my strongest driving pressure. And by chance it all labored out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. In just just a few months, we had been able to measure transportation via a person one-walled carbon nanotube. Determined by reduced-temperature experiments by a superb PhD pupil in my group, Sander Tans (now a valued colleague and professor at Delft University of Technological know-how by having an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with very extended (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Microbiology has only been around for any century, due to the fact we began to study micro-organisms much more significantly. I believed nanobiology was an acceptable expression, mainly because all molecular Organic suitable interactions occur for the nanoscale: a protein is some nanometres in sizing, DNA is two nm thick.’
All parameters were the identical for each panel In this particular movie, aside from the Original placement of the 6hb rod (proven in blue) within the nanopore. Simulations that terminated early resulting from translocation ceesdekker of your rod in the pore are marked by a gray background.
Instance (1) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim in the pore is highlighted in purple, as well as a 3D rendering in the motion with the DNA rod is shown.
The rotors harness Electricity from a nanoscale water and ion flow which is created by a static chemical or electrochemical likely gradient within the nanopore, that are established through a salt gradient or used voltage, respectively. These synthetic nanoengines self-Arrange and function autonomously in physiological problems, suggesting approaches to developing Strength-transducing motors at nanoscale interfaces.
There was a single challenge while — we didn't observe any measurable electrical conduction from the single polymer molecules. We concluded that at The one-molecule stage, conducting polymers have been essentially not such good conductors, which was instead disappointing. We Hence broadened our watch to test to search out additional promising molecules.
Example (4) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim from the pore is highlighted in red, in addition to a 3D rendering on the movement of the DNA rod is displayed.
2001, discovery of single-electron transistors at area temperature based upon nanotubes; realization of to start with logic circuits with carbon nanotube devices; and discovery from the molecular construction of DNA fix enzymes with AFM
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design in 2005. (nl)